This book is a detailed reference guide on Deep Learning and its applications. It aims to provide a basic understanding of Deep Learning and its different architectures that are applied to process images, speech, and natural language. It explains basic concepts and many modern use cases through fifteen chapters contributed by Computer Science academics and researchers. By the end of the book, the reader will become familiar with different Deep Learning approaches and models, and understand how to implement various Deep Learning algorithms using multiple frameworks and libraries. This book is divided into three parts. The first part explains the basic operating understanding, history, evolution, and challenges associated with Deep Learning. The basic concepts of mathematics and the hardware requirements for Deep Learning implementation, and some of its popular frameworks for medical applications are also covered. The second part is dedicated to sentiment analysis using Deep Learning and Machine Learning techniques. This book section covers the experimentation and application of deep learning techniques and architectures in real-world applications. It details the salient approaches, issues, and challenges in building ethically aligned machines. An approach inspired by traditional Eastern thought and wisdom is also presented. The final part covers Artificial Intelligence approaches used to explain the Machine Learning models that enhance transparency for the benefit of users.