"You should not have answered its call..." Professor Stephen Barlow is no longer a skeptic. Having faced the horrors of Chaythe Asylum, he turns his attention to the man responsible for the Third Ward Incident - the enigmatic Dr. Corvine - in the hopes of finding answers to his many questions. But some things, he soon learns, are better left lost to history. Traveling to a remote cabin in Michigan in search of the doctor and his research, Stephen finds himself descending deeper into a world of terror and madness. He and his students uncover the frightful truth about Corvine's experiments and realize that they may have unleashed something terrible in their meddling.