This book constitutes the refereed proceedings of the 13th International Conference on Advances in Optimization and Applications, OPTIMA 2022, held in Petrovac, Montenegro, during September 26-30, 2022.The 13 full papers included in this book were carefully reviewed and selected from 26 submissions. They were organized in topical sections as mathematical programming; global optimization; discrete and combinatorial optimization; optimization and data analysis; game theory and mathematical economics; and applications.