From organized drug dealers with super-henchman to end-of-the-world cultists, the world is full of threats that need to be faced with an Assembly of heroes. The mystic Dr. Piano has put together such a group, including Italian strongman Maciste, super-speedster Buzz, and combat specialist Champion, along with super-technician Dr. Gorgeous. They're ready to face the world. Except Champion's past turns out to be relevant to their biggest challenge. She used to be a guy until "blessed" by a goddess. And now those cultists think she would make the perfect sacrifice to bring about the end of the world!