Data Science: A First Introduction focuses on using the R programming language in Jupyter notebooks to perform data manipulation and cleaning, create effective visualizations, and extract insights from data using classification, regression, clustering, and inference. The text emphasizes workflows that are clear, reproducible, and shareable, and includes coverage of the basics of version control. All source code is available online, demonstrating the use of good reproducible project workflows. Based on educational research and active learning principles, the book uses a modern approach to R and includes accompanying autograded Jupyter worksheets for interactive, self-directed learning. The book will leave readers well-prepared for Data Science projects. The use of Jupyter notebooks for exercises immediately places the student in an environment that encourages auditability and reproducibility of analyses. The integration of Git and GitHub into the course is a key tool for teaching about collaboration and community, key concepts that are critical to Data Science. The book is designed for learners from all disciplines with minimal prior knowledge of mathematics and programming. The authors have honed the material through years of experience teaching thousands of undergraduates in the University of British Columbia’s DSCI100: Introduction to Data Science course.