This book developed from the need to teach a linear algebra course to students focused on data science and bioinformatics programs. These students tend not to realize the importance of linear algebra in applied sciences, since traditional linear algebra courses tend to cover mathematical contexts but not the computational aspect of linear algebra or its applications to data science and bioinformatics.The author presents the topics in a traditional course, yet offers lectures as well as lab exercises on simulated and empirical data sets. This textbook provides students a theoretical basis which can then be applied to the practical R and python problems, providing the tools needed for real-world applications.