Foundations of Data Science with Python introduces readers to the fundamentals of Data Science, including data manipulation and visualization, probability, statistics, and dimensionality reduction. This book is targeted toward engineers and scientists, but it should be readily understandable to anyone who knows basic calculus and the essentials of computer programming. It uses a computational-first approach to Data Science: the reader will learn how to use Python and the associated data-science libraries to visualize, transform, and model data, as well as how to conduct statistical tests using real data sets. Rather than relying on obscure formulas that only apply to very specific statistical tests, this book teaches readers how to perform statistical tests via resampling; this is a simple and general approach to conducting statistical tests using simulations that draw samples from the data being analyzed. The statistical techniques and tools are explained and demonstrated using a diverse collection of data sets to conduct statistical tests related to contemporary topics. This book can be used as an undergraduate textbook for an Introduction to Data Science course or to provide a more contemporary approach in courses like Engineering Statistics.