In the ever-evolving landscape of technology, Machine Learning stands as a beacon of innovation with the potential to reshape industries and redefine our daily lives. As editors of this comprehensive reference book, Methodologies, Frameworks, and Applications of Machine Learning, we are thrilled to present a compendium that encapsulates the essence of the latest advancements, theoretical foundations, and practical applications in the realm of Machine Learning. Technology is constantly evolving, and Machine Learning is positioned to become a pivotal tool with the power to transform industries and revolutionize everyday life. This book underscores the urgency of leveraging the latest Machine Learning methodologies and theoretical advancements, all while harnessing a wealth of realistic data and affordable computational resources. Machine Learning is no longer confined to theoretical domains; it is now a vital component in healthcare, manufacturing, education, finance, law enforcement, and marketing, ushering in an era of data-driven decision-making. The Chapter 2 focuses on practical implementations of Machine Learning projects using Scikit-learn and TensorFlow libraries in Python. Four distinct projects unfold, each addressing classification, regression, and image classification problems. The step-by-step walkthrough covers model evaluation using classical Machine Learning techniques and deep neural networks.