Eric Vance has managed to reach his ex-wife and daughter while avoiding hordes of the infected and a rogue scientist. However, they are still stuck in the quarantine zone. Trapped among the victims of the rot, a deadly disease turning its victims into either mindless zombies or ruthless predators, both seeking to spread the disease. He takes his family and other survivors they have met along the way to an old army buddy turned survivalist's who has fashioned a homemade underground bunker. They hope Vance's paranoid friend may have a way out of the quarantine zone, but even the man preparing for the end of the world was not prepared for the rot.