This book constitutes the refereed proceedings of the 18th International Conference on Information Security and Cryptology, Inscrypt 2022, held in Beijing, China during December 11-13, 2022. The 23 full papers and 3 short papers included in this book were carefully reviewed and selected from 68 submissions. They were organized in topical sections as Block Ciphers, Public key Encryption and u0026 Signature, Quantum, MPC, Cryptanalysis, Mathematical aspects of Crypto, Stream ciphers, Malware, Lattices.