Cholera is a life-threatening diarrheal disease that can spread rapidly and in explosive epidemics from one region to another, affecting large numbers of people. V. cholerae, a gram-negative motile bacterium, is the causative agent of this intestinal disease. This book presents topical research from across the globe in the study of cholera; its symptoms, diagnosis and treatment. Some topics discussed, herein, include emergence of new virulence factors of vibrio cholera as potential vaccine candidates, possible targets for quorum quenching of vibrio cholerae, the environmental reservoirs and vector of vibrio cholerae, and current African perspectives of cholera.