This book constitutes the refereed proceedings of the 28th Argentine Congress on Computer Science, CACIC 2022, held in La Rioja, Argentina, during October 3-6, 2022. The 20 full papers included in this book were carefully reviewed and selected from 184 submissions. They were organized in topical sections as Agents and Systems; Technology Applied to Education; Graphic Computation, Images and Visualization; Software Engineering; Databases and Data Mining; Hardware Architectures, Networks, and Operating Systems; Innovation in Software Systems; Signal Processing and Real-Time Systems; Innovation in Computer Science Education; and Digital Goverance and Smart Cities.