This book constitutes the refereed proceedings of the XXIst International Conference of the Italian Association for Artificial Intelligence on AIxIA 2022 - Advances in Artificial Intelligence, which was held in Udine, Italy, during November 28-December 2, 2022.The 33 full papers and 1 invited paper presented in this volume were carefully reviewed and selected from 54 submissions. They were organized in topical sections as Hybrid Approaches; Graphs and Networks; Multiagent Systems; Automated Planning and Scheduling; AI Applications; Miscellany; Natural Language Processing; and Keynote talk.