The use of human subjects in medical and scientific research has given rise to troubling ethical questions How should human subjects be selected for experiments What should they be told about the research in which they are involved How can their privacy be protected When is it permissible to deceive them How do we deal with subjects such as children fetuses and the mentally infirm for whom informed consent is impossible In this book Dr Robert J Levine reviews federal regulations ethical analysis and case studies in an attempt to answer these questions His book is an essential reference for everyone members of institutional review boards scientists philosophers lawyers addressing the ethical issues involved Levine s experience as a clinician IRB chairman writer and editor of a journal devoted exclusively to issues faced by IRBS makes him uniquely qualified to bring together the legal ethical and practical dimensions The book is sophisticated but readable and should be on every IRB administrator s desk and in every medical ethics library Norman Fost M D The New England Journal of Medicine Levine is one of the foremost historians of contemporary clinical science His book is at once a guide to primary sources for the history of clinical research in the late twentieth century and a pioneering secondary source about that history Daniel M Fox Bulletin of the History of Medicine You will be charmed by the book s elegance and lucidity and persuaded of its relevance to doctors in any country Alex Paton British Medical Journal Should be of wide interest to those keen to see advances in medical research brought into general medical practice Gilbert Omenn Issues in Science and Technology