This book describes different mathematical modeling and soft computing techniques used to solve practical engineering problems. It gives an overview of the current state of soft computing techniques and describes the advantages and disadvantages of soft computing compared to traditional hard computing techniques. Through examples and case studies, the editors demonstrate and describe how problems with inherent uncertainty can be addressed and eventually solved through the aid of numerical models and methods. The chapters address several applications and examples in bioengineering science, drug delivery, solving inventory issues, Industry 4.0, augmented reality and weather forecasting. Other examples include solving fuzzy-shortest-path problems by introducing a new distance and ranking functions. Because, in practice, problems arise with uncertain data and most of them cannot be solved exactly and easily, the main objective is to develop models that deliver solutions with the aid of numerical methods.