Manuscripts have played a crucial role in the educational practices of virtually all cultures that have a history of using them. As learning and teaching tools, manuscripts become primary witnesses for reconstructing and studying didactic and research activities and methodologies from elementary levels to the most advanced.The present volume investigates the relation between manuscripts and educational practices focusing on four particular research educational teachers, students and their manuscripts; organising syllabi; exegetical annotations; modifying adaptations.The volume offers a number of case studies stretching across geophysical boundaries from Western Europe to South-East Asia, with a time span ranging from the second millennium BCE to the twentieth century CE.