This monograph is a collection of selected articles on the subject of mood disorders such as depression and schizophrenia. It is divided into 3 1) Research methods in psychopharmacology - which highlights some established experimental techniques to study mood disorders in human and relevant animal models, 2) Pathophysiology of mood disorders - which explains the physiological and pharmacological mechanisms responsible for mood disorders and 3) New strategies for the treatment of mood disorders - a concluding section that provides recent examples on the beneficial effects of pharmacological and non-pharmacological interventions in the relief of mood disorders. The book serves as a primer for graduate students and researchers interested in the physiology and treatment of affective psychological disorders.