This book integrates the current basic and clinical knowledge in the area of biophysical stimulation of osteoblast for in vitro and in vivo live bone generation. This innovative methodology and its applications are presented and discussed in several clinical treatment of fracture nonunion, spine stabilization, bone replacement after tumor resections, stabilization of failed joint endoprostheses in revision surgery and in treatment of bone loss (osteoporosis and osteopenia).The author analyses different types of biophysical stimulation of osteoblasts for bone regeneration, e.g. mechanical (static and alternating, including distraction osteogenesis), electromagnetic (pulsed, alternating, static), light (at different spectrum range, including laser), acoustic (including ultrasound), RF etc. Moreover, he summarizes and discusses the most significant findings for in vitro bone generation and its resulting clinical use as autologous bone graft without surgical morbidity.Reflecting the author's extensive experience this book is an excellent source of knowledge and a valuable aid to clinical practice for all orthopedic surgeons, fellows, and researchers wanting to gain insights into this promising field.