The manual provides information on the local immunity of the mucous membranes of the upper respiratory tract and the skin of the external auditory meatus. Introductory chapters contain information about the origin of immunocompetent cells (leukocytes, neutrophil granulocytes, monocytomacrophages, lymphocytes, eosinophils), time spent in tissues, duration of life, participation in immune reactions. The materials are based on the data of scientific literature, own developments and scientific research of the authors.