The guide provides the classification and clinical pharmacology of drugs used in the treatment of emergencies caused by pathologies of the cardiovascular and respiratory systems, diseases of the gastrointestinal tract, kidneys, endocrine and hematological diseases, neurological and psychiatric disorders, allergies, infections, acute poisoning. Typical clinical manifestations, modern approaches to diagnosis, basic principles and treatment regimens for emergencies with levels of evidence are described. Background information facilitating rational individualized drug administration and choice of treatment regimen is widely presented.