The book is devoted to the use of the MATLAB matrix system in radio engineering calculations and in the modeling of electronic devices and systems. For the first time, the latest versions of MATLAB are described with extension packages Simulink, Signal Processing Toolbox, Filter Design Toolbox, RF Toolbox and Blockset, Wavelet Toolbox, Control Systems, SimPowerSystems, etc. The latest Simscape and SimElectronics electronic circuit modeling packages are described. Along with the functions of the command mode of operation, an interactive and visually oriented package toolkit with a graphical GUI user interface and mathematical modeling of systems and devices in the Simulink environment are described. Integration of MATLAB with modern digital radio measuring instruments and virtual laboratories for instrument control and processing of real oscillograms is described.