In the mid-fourteenth century the Black Death ravaged Europe, leading to dramatic population drop and social upheavals. Recurring plague outbreaks together with social factors pushed Europe into a deep crisis that lasted for more than a century. The plague and the crisis, and in particular their short-term and long-term consequences for society, have been the matter of continuous debate. Most of the research so far has been based on the study of written sources, and the dominating perspective has been the one of economic history. A different approach is presented here by using evidence and techniques from archaeology and the natural sciences.