The book discusses the most important issues of epistemology - the problems of scientific realism, relativization of knowledge, scientific objectivity, scientific rationality - in the context of the content of modern science, which is denoted in the literature by the term "post-classical science." Their actualization is due to the appeal of modern science to the study of complex self-developing systems. The author shows that process philosophy and evolutionary epistemology are organized into a single construct, the philosophical foundation of post-classical science. Evolutionary epistemology as a cognitive practice that defines cognitive activity, and the evolutionary-synergistic paradigm as the core of post-classical science are those landmarks that allow constructive discussion of the problems posed. The book is addressed to those who are interested in issues of epistemology and philosophy of science. It can be useful for graduate students as material on the program of the candidate exam "History and Philosophy of Science."