The textbook describes the differential diagnosis and treatment of the main syndromes that are most often found in the therapist's practice - thrombotic, cardialgic, coronary, hypertensive, asthmatic, dyspeptic, anemic, hemorrhagic, articular, urinary; arrhythmia syndrome, "acute" abdomen, jaundice, hepatomegaly, etc. The algorithms of differential diagnosis and treatment of pathology of internal organs presented by the authors from the perspective of a syndromic approach will allow students and young doctors to effectively assimilate the material and prepare for exams, as well as develop clinical thinking, learn to quickly navigate the manifestations of a particular syndrome and adequately treat it.