The manual provides up-to-date data on the biological, clinical, therapeutic, social, preventive, legal and ethical aspects of addiction. The first volume discusses the mechanisms of etiopotogenesis of narcological diseases and the toxic effect of psychoactive substances (surfactants), the problems of immunity in alcoholism and drug addiction. Combinations of genetic, personal and environmental factors of development of dependence on surfactants were analyzed. The classification of narcological diseases is given, the clinic of their various forms is described in detail, including in the case of combination with endogenous diseases.