The new edition of the classic textbook "Medical Physiology" retains all the traditions of Arthur C. Guyton and John E. Hall in presenting key concepts of physiology. The textbook is divided into short and easy-to-read chapters, contains many tables and drawings (over 1200) for analyzing information, covers all the main systems of the human body and reflects the latest information in the field of medical physiology. The discussion of basic concepts is accompanied by clinical examples and descriptions of molecular cellular mechanisms important from the point of view of practical medicine. Particular attention is paid to the interaction of the main systems of the body, homeostasis issues and pathophysiological problems. This publication is primarily intended for students and graduate students of medical and biological faculties of higher educational institutions.