The manual is a fundamental work on clinical nephrology, in the creation of which leading specialists from various fields of nephrology took part. The manual consists of two volumes. The first volume sets out from the standpoint of modern science the physiology and morphology of the kidneys, as well as some other theoretical issues, knowledge of which is necessary for a clinician. The methods of studying people suffering from kidney diseases, the most important clinical syndromes - acute and chronic renal failure, nephrotic syndrome, renal hypertension.