The manual covers general issues of pancreatology: etiology, pathogenesis, risk factors for various pancreatic lesions and pathomorphology of its diseases. At the modern level, diagnostics is presented, including the latest methods of functional and instrumental research. The indications for surgical treatment and the technique of operations are described in detail. For the first time in the domestic literature, a new section of pancreatic surgery is described in detail - the treatment of its hormone-producing tumors.