The monograph is devoted to the consideration of integration trends in education, which resulted, in particular, in the formation of various options for a synergistic approach to the development of the content of natural and mathematical disciplines. Developing the ideas of his predecessors about the synergistic laws of the learning process, the author proposes his concept of a natural science approach to the analysis of information exchange processes, within the framework of which he developed a methodology for coordinating the content of natural and mathematical education, which makes it possible to effectively coordinate the content of various topics (modules) within one discipline (physics, chemistry, biology, mathematics); various natural-mathematical disciplines among themselves; natural-mathematical and humanitarian disciplines; natural and mathematical education with the content of the achievements of modern science.