The manual presents the latest data on the pathogenesis, clinical, laboratory, instrumental signs of such diseases of the biliary tract as dysfunction of the gallbladder and sphincter Oddi, cholecystitis, cholelithiasis. The manual introduces the main clinical manifestations of diseases, modern research methods, such as fractional chromatic duodenal sensing, microscopy and biochemical examination of bile, various radiological methods, including CT and MRI, ultrasound diagnostics.