The book reflects the main issues of pain and pain relief in dentistry. Much attention is paid to the psycho-emotional state of patients at the dental appointment. Detailed characteristics of local anesthetics used in dentistry are given, as well as recommendations for their use. Data on local anesthetics synthesized in Kazakhstan are presented. The modern technological provision of local anesthesia and the main methods of its implementation are described. Designed for practical doctors and students of dental faculties of universities.