This book provides various insights into Machine Learning techniques in healthcare system data and its analysis. Recent technological advancements in the healthcare system represent cutting-edge innovations and global research successes in performance modelling, analysis, and applications. The extensive use of machine learning in numerous industries, including healthcare, has been made possible by advancements in data technologies, including storage capacity, processing capability, and data transit speeds. The need for a personalized medicine or ""precision medicine"" approach to healthcare has been highlighted by current trends in medicine due to the complexity of providing effective healthcare to each individual. Personalized medicine aims to identify, forecast, and analyze diagnostic decisions using vast volumes of healthcare data so that doctors may then apply them to each unique patient. These data may include, but are not limited to, information on a person's genes or family history, medical imaging data, drug combinations, patient health outcomes at the community level, and natural language processing (NLP) of pre-existing medical documentation.