The principles of creation and design of pulse-periodic nanosecond electron accelerators are described, and development technology and specific radiation technologies based thereon, The development of the technique of generating high-voltage pulses of nanosecond duration based on the effect of nanosecond current interruption in semiconductor diodes created the prerequisites for the development of nanosecond electron accelerators of a pulse-periodic mode of action, Such accelerators generate beams of large cross-section with high intensity, having a strong biological effect. However, in order to create industrial accelerators and implement highly efficient radiation technologies, it is necessary to ensure the required range of beam parameters, high reliability and resource of accelerators. Examples of the use of created accelerators in various branches of science and technology are considered, in particular, for radiation sterilization and disinfection of medical and food products, raw materials of animal and plant origin, guidance of defects in solids, in radiation-chemical technologies, etc. Issues of measuring parameters of electronic beams, monitoring parameters and automation of accelerator control are presented.