Educational manual "Clinical physiology in intensive care," ed., A.N. Shmakova, considers the issues of clinical physiology of critical conditions in pediatrics. The questions of age physiology in the aspect of anesthesiology and resuscitation are described. Critical condition syndromes are highlighted: ischemia-reperfusion, coagulopathy, acute cerebral insufficiency, shock, acute respiratory failure, gastrointestial, renal and hepatic insufficiency. Pediatric toxicology issues presented.