This book provides a comprehensive overview of manufacturing systems, their role in productprocess design, and their interconnection with an Industry 4.0 perspective, especially related to design, manufacturing, and operations. Handbook of Manufacturing Systems and Design: An Industry 4.0 Perspective provides the knowledge related to the theories and concepts of Industry 4.0. It focuses on the different types of manufacturing systems in Industry 4.0 along with associated design, and control strategies. It concentrates on the operations in Industry 4.0 with a particular focus on supply chain, logistics, risk management, and reverse engineering perspectives. Offering basic concepts and applications through to advanced topics, the handbook feeds into the goal of being a source of knowledge as well as a vehicle to explore the future possibilities of design, techniques, methods, and operations associated with Industry 4.0. Concepts with practical applications in the form of case studies are added to each chapter to round out the many attributes this handbook offers. Manufacturing systems have undergone a massive transformation in the past decade, and the concept of Industry 4.0 has significantly shaped this evolution. Industry 4.0 refers to integrating advanced technologies such as Internet of Things (IoT), Artificial Intelligence (AI), and cyber-physical systems into manufacturing processes to create smart factories capable of autonomous decision-making and optimization.