Hormone therapy is firmly established in all areas of medicine. However, there are a number of contraindications to hormone treatment. Until now, all hormones are prescribed in average doses. That is, by and large, patients with each administration of the drug deal a powerful blow to their tissue receptors, which have to "learn," roughly speaking, not so actively respond to the stimulus. It is not difficult to guess how it will end: their sensitivity to hormonal drugs gradually decreases, and then disappears altogether.