The purpose of this handbook is to allow users to learn and master the mathematics software package MATLAB®, as well as to serve as a quick reference to some of the most used instructions in the package. A unique feature of this handbook is that it can be used by the novice and by experienced users alike. For experienced users, it has four chapters with examples and applications in engineering, finance, physics, and optimization. Exercises are included, along with solutions available for the interested reader on the book’s web page. These exercises are a complement for the interested reader who wishes to get a deeper understanding of MATLAB.