The monograph is devoted to the physical justification and application in medicine of the concept of "Electroepidermal resistance" (EES). The EPS assessment method is easy to use, does not require special patient training, including skin surface treatment; can be used in the field. It is effective in rapid diagnostics when searching for the topography of the pathological focus, especially at the early stages of its development, in the differential diagnosis of diseases. Rapid detection of the topography of the pathological process will reduce the time for directed in-depth examination of the patient.