Book of American specialists describing the current state of organization of DNA sequence data banks and the main algorithms used in their analysis. Mathematical results underlying algorithms for sequence alignment of functional regions, prediction of secondary and tertiary structures based on the primary structure and determination of the degree of proximity of different sequences are presented. The book contains many illustrations and program texts for many algorithms, can serve as an introduction to a new scientific discipline - computer genetics. For applied mathematicians, programmers, molecular biologists, graduate students and university students.