The publication is devoted to the work in the Yenisei Siberia of the expedition of Daniel Gottlieb Messerschmidt, personally accepted into the Russian service by Peter I. It laid the foundation for the scientific study of Siberia. One of the longest and most fruitful stages of the expedition's work took place on the territory of the Yenisei Siberia (1721-1723, 1725). The book is addressed to everyone who is interested in the history of Russia, Siberia and the Krasnoyarsk Territory, who is interested in the regional history and history of academic scientific expeditions, and will be useful for educational purposes for teachers of higher and secondary schools, graduate students, students.