The advances in semiconductor detectors, scintillators, photodetectors such as silicon photomultipliers (SiPM), and reaodut electronics have experienced tremendous growth in recent years in terms of basic technologies and variety of applications.The second edition of the book Radiation Detection Systems presents variety of radiation detection systems giving readers a broad view of the state-of–the-art in the design of detectors, front-end electronics and systems offering optimized choices of the detection tools for a particular application.