The basic principles and methods of technical level management in the implementation of the system organization for design, modeling and technological support for the manufacture of VLSI of the "system-on-a-chip" type, a concept has been developed for building an infrastructure for end-to-end design of complex-functional VLSIs from the system level to the crystal topology, selection of the technological basis for the manufacture of VLSI, taking into account the provision of special requirements for radiation resistance, organization of the process of manufacturing photomasks and microcircuits, their subsequent testing, assembly, testing and use.