A practical guide focuses on the most important issue in environmental analytical chemistry. A modern methodology for determining priority pollutants in natural and wastewater is considered, based on the use of a combination of effective sample preparation methods (TFE, TFME, extraction on a magnetic stirrer stick, etc.) with informative analysis methods (HCMS, HCIC-Fourier, HPLCMS, HCVEZHMSIK - Fourier, GCHMSAED, ISPMS, ISPAMES, etc.), which makes it possible to identify and quantify target compounds. Official (standard) domestic and foreign (EU, USA) methods for the detection of toxic organic and organometallic compounds and heavy metals are given. For professionals in the field of analytical chemistry, employees of SES and environmental laboratories, students of chemical and medical universities.