Python is becoming increasingly popular among data scientists. However, analysis and visualization tools need to interact with the data stored in various formats such as relational and NOSQL databases.This book aims to make the reader proficient in interacting with databases such as MySQL, SQLite, MongoDB, and Cassandra.This book assumes that the reader has no prior knowledge of programming. Hence, basic programming concepts, key concepts of OOP, serialization and data persistence have been explained in such a way that it is easy to understand. NOSQL is an emerging technology. Using MongoDB and Cassandra, the two widely used NOSQL databases are explained in detail.