The second edition of the textbook presents in detail those sections of physical and colloidal chemistry that are necessary for the study of medicine. The basic laws of physical and colloidal chemistry are illustrated by examples from biology, theoretical and practical medicine. The textbook deals with issues related to the aggregate state of substances, outlines some issues of thermodynamics, considers reversible and irreversible processes, as well as the phenomena of adsorption and catalysis. The material is presented taking into account the latest developments in the field of physical and colloidal chemistry.