The monograph contains the materials of the research of the Federal State Budgetary Scientific Institution "Ural Research Institute of Agricultural Sciences" and Ural State Agrarian University, carried out in recent years in the field of immunity and plant protection. The main harmful organisms, their biological features and harmfulness are described, as well as the most effective comprehensive measures to combat them, taking into account zonal features. The effectiveness of protective control measures in the cultivation of grain, vegetable crops, berry shrubs and fruit trees has been shown. The need to increase the culture of agriculture in combination with the use of protective equipment in crop cultivation technologies is disclosed. The book "Plant Protection in the Middle Urals" is intended for a wide range of agricultural specialists, generalized materials are useful for teachers, graduate students and students of secondary and higher educational institutions studying plant protection issues.