This book discusses state-of-the-art reviews of the existing Machine Learning techniques and algorithms including hybridizations and optimizations. It covers applications of Machine Learning via Artificial Intelligence (AI) prediction tools, the discovery of drugs, neuroscience, diagnosis in multiple imaging modalities, pattern recognition approaches to functional magnetic resonance imaging, image and speech recognition, automatic language translation, medical diagnostic, stock market prediction, traffic prediction, and product automation. In recent years, the fusion of Machine Learning methodologies with optimization techniques has significantly advanced the realm of intelligent applications across diverse domains. This book delves into the symbiotic relationship between Machine Learning hybridization and optimization, presenting a comprehensive exploration of their integration to empower intelligent systems. The amalgamation of Machine Learning and optimization has revolutionized the way we approach problem-solving, enabling us to create sophisticated applications that adapt, evolve, and enhance their performance over time. This synergy has paved the way for innovation in various fields, from healthcare and finance to manufacturing and beyond. This book is aimed at graduate students and researchers in Machine Learning, Artificial Intelligence, and electrical engineering.